α-Alkylation of Carbonyl Compounds by Addition of
Alcohols to Enol Acetates

Y. Nishimoto; Y. Onishi; M. Yasuda; A. Baba

doi:10.1055/s-0029-1219062

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Synfacts 2010(2): 0222-0222
DOI: 10.1055/s-0029-1219062

Metal-Mediated Synthesis

α-Alkylation of Carbonyl Compounds by Addition of Alcohols to Enol Acetates

Contributor(s): Paul Knochel, Andreas J. Wagner
Y. Nishimoto, Y. Onishi, M. Yasuda, A. Baba*
Osaka University, Japan

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Publication History

Publication Date:
21 January 2010 (online)

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Significance

The authors have developed a new procedure for the α-alkylation of aldehydes and ketones that involves the direct use of alcohols and enol acetates in the presence of either InI₃, GaBr₃ or FeBr₃ as catalyst. The reaction is applicable to various types of alcohols and enol acetates.