Synfacts 2010(2): 0146-0146  
DOI: 10.1055/s-0029-1219037
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of WAY-315193

Contributor(s): Philip Kocienski
et al. A. Alimardanov*
Wyeth Research, Pearl River, New York and Wyeth Research, Collegeville, USA
Further Information

Publication History

Publication Date:
21 January 2010 (online)

Significance

Norepinephrine transporter inhibitors are candidates for treating depression, urinary incontinence, vasomotor symptoms and pain. The synthesis of candidate WAY-315193 features a rare large-scale application of the Sharpless-Katsuki epoxidation. For another large-scale Sharpless-Katsuki epoxidation, see K. E. Henegar, M. Cebula Org. Process Res. Dev. 2007, 11, 354.