Abstract
A selection of carbon-fluorine bond-forming reactions
is presented with particular focus on transition-metal-mediated
fluorination. A brief summary of conventional fluorination reactions
is followed by a discussion of fluorination reactions mediated by
palladium and silver. Investigations into the mechanism as well
as the conceptual difficulty associated with transition-metal-mediated
carbon-fluorine bond formation are presented.
1 Introduction
2 Nucleophilic Fluorination
3 Electrophilic Fluorination
4 Balz-Schiemann Reaction
5 Palladium-Mediated C-X Bond Formation
6 Palladium-Mediated Nucleophilic Fluorination
7 Palladium-Mediated Directed Electrophilic Fluorination
8 Palladium-Mediated Electrophilic Fluorination
9 Silver-Mediated Fluorination
10 Conclusion
Key words
carbon-fluorine bond formation - transition
metals - palladium - silver - catalysis
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