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Synfacts 2009(9): 0997-0997  
DOI: 10.1055/s-0029-1217666
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Stereoselective Two-Directional Elongation of 1,3-Polyols

Contributor(s): Hisashi Yamamoto, Zhi Li
Y. Lu, I. S. Kim, A. Hassan, D. J. Del Valle, M. J. Krische*
University of Texas at Austin, USA
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Publikationsdatum:
21. August 2009 (online)

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Significance

1,3-Polyols are highly important motifs in many polyketide natural products. Instead of traditional allylboration or various other methods, the authors prepared 1,3-polyols via an iridium-catalyzed pathway, and very high enantio- and diastereoselectivities can be achieved.