Synfacts 2009(7): 0703-0703
Synthesis of Natural Products and Potential Drugs© Georg Thieme Verlag Stuttgart ˙ New York
Synthesis of Nakiterpiosin
S. Gao, Q. Wang, C. Chen*
The University of Texas Southwestern Medical Center at Dallas, USA
22 June 2009 (online)
The synthesis of nakiterpiosin, a cytotoxic sponge metabolite, features a Pd-catalyzed carbonylative cross-coupling (K → L) followed by a photo-Nazarov cyclization (L → M) to create the indanone moiety.