Copper-Catalyzed Hydroalkylation
of Alkynes: Addition of sp³ C-H Bonds Across
Carbon-Carbon Triple Bonds

Lehao Huang; Kai Cheng; Bangben Yao; Jinlong Zhao; Yuhong Zhang

doi:10.1055/s-0029-1216991

SPECIALTOPIC

Copper-Catalyzed Hydroalkylation of Alkynes: Addition of sp^³ C-H Bonds Across Carbon-Carbon Triple Bonds

Lehao Huang, Kai Cheng, Bangben Yao, Jinlong Zhao, Yuhong Zhang*
Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China
Fax: +86(571)87953244; e-Mail: yhzhang@zju.edu.cn;

Abstract

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Abstract

The regioselective copper-catalyzed addition of sp^³ C-H bonds adjacent to an oxygen atom to various alkynes has been accomplished under mild reactions conditions in the presence of tert-butyl hydroperoxide to give the corresponding alkenylated products.

Key words

C-H activation - copper - addition reactions - alkynes - tert-butyl hydroperoxide

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References

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Copper-Catalyzed Hydroalkylation of Alkynes: Addition of sp³ C-H Bonds Across Carbon-Carbon Triple Bonds

Copper-Catalyzed Hydroalkylation of Alkynes: Addition of sp^³ C-H Bonds Across Carbon-Carbon Triple Bonds