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Synfacts 2009(6): 0642-0642  
DOI: 10.1055/s-0029-1216779
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Bismuth-Catalyzed Multicatalytic Synthesis of Tetrahydrofurans

Contributor(s): Mark Lautens, Jacki Kitching
B. D. Kelly, J. M. Allen, R. E. Tundel, T. H. Lambert*
Columbia University, New York, USA
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Publication History

Publication Date:
25 May 2009 (online)

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Significance

The bismuth-catalyzed synthesis of complex tetrahydrofurans is described. This one-pot multicatalytic process involves nucleophilic addition followed by hydroalkoxylation and affords tetrahydrofurans in good yield and with good dia­stereoselectivity.