Nickel-Catalyzed Coupling of Alkyl Halides and Alkyl Grignard Reagents

Significance

Grignard reagents are desirable nucleophiles in coupling reactions, since they are inexpensive and easy to prepare. The use of a
pincer nickel complex (1) enables their highly efficient sp^³-sp^³ cross-coupling with alkyl bromides and iodides. The reaction proceeds at low temperatures, so that even highly reactive functionalities like ketones are tolerated.