Beta-cell replacement either by pancreas or islet transplantation is the only treatment
to achieve an insulin-independent, constantly normoglycemic state avoiding hypoglycemic
episodes in patients with type-1 diabetes mellitus. This article reviews the worldwide
experience with these treatments and reports the very recent progress as well as the
perspectives of islet transplants in non-uremic patients.
Pancreas transplantation - islet transplantation - end-stage renal disease - kidney
transplantation - allo-autoimmunity - immunosuppression - immunotolerance
