Effects of Progesterone and Estradiol on Aminopeptidase A (AAP) and Leucine Aminopeptidase (LAP) Activities in the Pregnancy Serum and Placenta of the Rat

O. Kurauchi; S. Mizutani; S. Nomura; R. Hotta; Y. Ito; Y. Asada; M. Furuhashi; M. Kasugai; Y. Tomoda

doi:10.1055/s-0029-1210841

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 1989; 93(1): 90-94
DOI: 10.1055/s-0029-1210841

Original

Effects of Progesterone and Estradiol on Aminopeptidase A (AAP) and Leucine Aminopeptidase (LAP) Activities in the Pregnancy Serum and Placenta of the Rat

O. Kurauchi, S. Mizutani, S. Nomura, R. Hotta, Y. Ito, Y. Asada, M. Furuhashi, M. Kasugai, Y. Tomoda

Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan

Abstract

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Summary

We investigated the effects of estradiol and progesterone on placental aminopeptidase A and leucine aminopeptidase activities in pregnant rats. Estradiol (0.5, 1.0 and 2 mg/day) plus progesterone (5, 10 and 20 mg/day) was given for five days starting from the 16th day. Changes in both enzyme activities in the serum, placental cytosol and microsome caused by the steroids were analyzed. Aminopeptidase A activities in all three compartments and leucine aminopeptidase activities in the serum and cytosol were stimulated by estradiol (1.0 mg/day) plus progesterone (10 mg/day). Since we previously found that the placental aminopeptidases degrade peptide hormones, our present study suggests that steroids effect the metabolism of peptide hormones of fetal and/or maternal origin.

Key Words

Aminopeptidase A - Leucine aminopeptidase - Progesterone - Estradiol

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