Machilin A Isolated from Myristica fragrans Stimulates Osteoblast Differentiation

Abstract

This study evaluated the stimulatory effects of machilin A and structurally related lignans isolated from Myristica fragrans on osteoblast differentiation. In two in vitro osteoblast differentiation models, machilin A stimulated osteoblast differentiation via activation of p38 MAP kinase. Lignans isolated from Myristica fragrans also stimulated osteoblast differentiation in MC3T3-E1 cells; the lignans included macelignan, machilin F, nectandrin B, safrole, licarin A, licarin B, myristargenol, and meso-dihydroguaiaretic acid. These data suggest that lignans isolated from Myristica fragrans have anabolic activity in bone metabolism.

Abbreviations

ALP:alkaline phosphatase

COLI:type I collagen

MAP:mitogen-activated protein

OCN:osteocalcin

OPN:osteopontin

machilin A - Myristica fragrans - Myristicaceae - lignan - osteoblast differentiation

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