¹⁸F-DOPA-PET bei neuroendokrinen Tumoren (NET)

Zusammenfassung

Der Nachweis von NET mittels planarer Szintigrafie oder Single-Photonen-Emissions-Tomografie (SPECT) ist gerade bei kleinen Befunden trotz spezifischer Radiopharmaka wie ¹¹¹In-Octreotid oder ¹²³I-MIBG durch die begrenzte Auflösung der Gammakamera limitiert. Die Positronenemissionstomografie (PET) hat gegenüber der konventionellen Bildgebung den Vorteil der höheren Ortsauflösung, die bei onkologischen Fragestellung am häufigsten eingesetzte ¹⁸F-Fluordesoxyglukose ist jedoch eher zum Nachweis von entdifferenzierten NET geeignet. Für den Einsatz der ¹⁸F-DOPA-PET bei neuroendokrinen Tumoren liegen wenige, aber in Hinblick auf die Sensitivität des Tumornachweises, viel versprechende Studien vor. Der Stellenwert von ¹⁸F-DOPA im Vergleich zu den ⁶⁸Ga-markierten Somatostatinrezeptorliganden wird in Studien zu klären sein.

Abstract

Despite highly specific radiopharmaceuticals like ¹¹¹In-Octreotide or ¹²³I-MIBG, detection of small neuroendocrine tumours (NET) can be hampered due to the limited resolution of planar scintigraphy and SPECT. ¹⁸F-FDG, the workhorse in oncological high resolution PET diagnostic, is mainly positive in undifferentiated NETs. For ¹⁸F-DOPA, a limited number of studies are published, demonstrating favourable results in tumour detection of NETs. The role of ¹⁸F-DOPA in comparison to ⁶⁸Ga-labeled somatostatin-receptor ligands will have to be defined in future studies.

¹⁸F-DOPA - PET - Neuroendokrine Tumore

¹⁸F-DOPA - PET - neuroendocrine tumours

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