Abstract
Background: Due to the association of second generation antipsychotics (SGAs) with weight gain
and alterations of glucose and lipid homeostasis, we aimed to group six commonly prescribed
SGAs into classes of differing risks.
Methods: Twenty-eight patients meeting the criteria for a diagnosis of schizophrenic disorder
according to ICD-10 were assigned to monotherapy with olanzapine, clozapine, quetiapine,
amisulpride, ziprasidone or risperidone. The levels of glucose and lipid metabolism
were assessed before and after 28 days of treatment.
Results: Based on cluster analysis, olanzapine and clozapine were found to constitute a high-risk
group for metabolic dysregulation while amisulpride, quetiapine, risperidone and ziprasidone
could be assigned to a non-high-risk group. Subjects from the high-risk group displayed
significant weight gain with concomitant increases of HOMA-IR, levels of insulin,
total cholesterol, TG, LDL-C and leptin. No significant changes were observed in the
non-high-risk group.
Conclusion: The results of this study support the conclusion of the Consensus Development Conference
on Antipsychotic Drugs and Obesity and Diabetes that certain SGAs are associated with
a higher risk for weight gain, insulin resistance and dyslipidemia.
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Correspondence
C. F. EbenbichlerMD
Department of Internal Medicine I
Medical University Innsbruck
Anichstraße 35
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Austria
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eMail: Christoph.Ebenbichler@i-med.ac.at