Recovery of the Heart after Normothermic Ischemia Part I: Ultrastructural Findings during Postischemic Reperfusion

J. Mulch; J. Schaper; H. H. Scheld; F. W. Hehrlein

doi:10.1055/s-0028-1096212

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Thorac Cardiovasc Surg 1979; 27(1): 12-17
DOI: 10.1055/s-0028-1096212

Recovery of the Heart after Normothermic Ischemia Part I: Ultrastructural Findings during Postischemic Reperfusion

J. Mulch, J. Schaper, H. H. Scheld, F. W. Hehrlein

Department Cardiovascular Surgery, Justus-Liebig-University, Giessen

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Publikationsdatum:
10. Dezember 2008 (online)

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Summary

The influence of controlled ischemia on myocardial ultrastructure was investigated in isolated, metabolically supported canine hearts. Recovery of functionally normal tissue as indicated by the reversibility of morphological alterations was observed up to 60 minutes of anoxia. It was shown that prolonged reperfusion of the empty beating heart supports the recovery of normal cellular ultrastructure. Severe ischemic damage of mitochondria due to ischemia of 60 minutes was almost completely reversible after a reperfusion period of 50 minutes.

Key-Words:

Myocardial ultrastructure - Cardiac arrest - Recovery during reperfusion