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© Georg Thieme Verlag KG Stuttgart · New York
Relation Between the Coefficient of Sedimentation of Human Thyroglobulin and its Iodination Level[*]
08 January 2009 (online)
Sedimentation constant and iodination level of TG have been studied in 16 human normal and goitrous thyroid glands. S values are significantly reduced in poorly iodinated glands (17.8 ± 0.4 S, range: 17.2 to 18.6). The S values remain normal (19 ± 0.1 S) for a broad range of iodination levels and is only reduced below a critical iodination level which is situated at 0.1%.
Results support the hypothesis that the metabolic abnormalities in non-toxic goitre are related to a modification of the spatial configuration of the thyroglobulin molecule and occur at a critical level of iodination of this protein.
Thyroid Gland - Thyroglobulin Structure - Thyroid Iodination - Non-Toxic Goitre