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Horm Metab Res 1971; 3(6): 423-425
DOI: 10.1055/s-0028-1094116
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© Georg Thieme Verlag KG Stuttgart · New York

Relation Between the Coefficient of Sedimentation of Human Thyroglobulin and its Iodination Level[*]

M.  Camus , A. M. Ermans
  • Department of Radioisotopes, Saint-Pierre Hospital, Brussels, Belgium
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Sedimentation constant and iodination level of TG have been studied in 16 human normal and goitrous thyroid glands. S values are significantly reduced in poorly iodinated glands (17.8 ± 0.4 S, range: 17.2 to 18.6). The S values remain normal (19 ± 0.1 S) for a broad range of iodination levels and is only reduced below a critical iodination level which is situated at 0.1%.

Results support the hypothesis that the metabolic abnormalities in non-toxic goitre are related to a modification of the spatial configuration of the thyroglobulin molecule and occur at a critical level of iodination of this protein.

Key words

Thyroid Gland - Thyroglobulin Structure - Thyroid Iodination - Non-Toxic Goitre

1 Work carried out with the assistance of a grant from the National Fund of Scientific Research, under the ULB - PISA Euratom Contract, No 20.060.

1 Work carried out with the assistance of a grant from the National Fund of Scientific Research, under the ULB - PISA Euratom Contract, No 20.060.

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