© Georg Thieme Verlag KG Stuttgart · New York
Actions of Salbutamol in Late PregnancySerum Levels of Human Chorionic Gonadotropin, Human Placental Lactogen, Total Oestriol and Progesterone in Diabetic and Non-Diabetic Women during Infusion of Salbutamol
23 December 2008 (online)
The acute effects of salbutamol on the serum levels of hPL, hCG, oestriol and progesterone in diabetic and non-diabetic pregnant women in the last trimester were studied. I.V. administration of salbutamol in an increasing dose from 0 to 22.5 ug/min caused no change in hPL or hCG levels in any group. Progesterone showed a significant fall after 40 min in the diabetic group and a less pronounced, although still significant fall after 80 min in the non-diabetic group. The oestriol levels increased significantly after 40 min in the diabetic group while no significant change was noted in the non-diabetic group. It is speculated that the effects in the diabetic women might be explained by a redistribution of the available placental 5-pregnenolone due to an increased fetal conversion into oestriol. This might be due to an increased sensitivity of the adrenal cortex of these foetuses to a supposed stimulatory effect of salbutamol.
Pregnancy - Diabetes - Human Chorionic Gonadotrophin - Human Placental Lactogen - Oestriol - Progesterone