Download PDF
Horm Metab Res 1978; 10(5): 434-438
DOI: 10.1055/s-0028-1093408
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Actions of Salbutamol in Late Pregnancy

Serum Levels of Human Chorionic Gonadotropin, Human Placental Lactogen, Total Oestriol and Progesterone in Diabetic and Non-Diabetic Women during Infusion of SalbutamolK.  Carlström , N. O. Lunell , B.  Persson , J.  Wager
  • Hormone Laboratory, Department of Obstetrics and Gynecology, Sabbatsbergs Hospital, Department of Obstetrics and Gynecology, Huddinge Hospital and Department of Pediatrics, St. Görans Hospital, Karolinska Institute, Stockholm, Sweden
Further Information

Publication History

Publication Date:
23 December 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

The acute effects of salbutamol on the serum levels of hPL, hCG, oestriol and progesterone in diabetic and non-diabetic pregnant women in the last trimester were studied. I.V. administration of salbutamol in an increasing dose from 0 to 22.5 ug/min caused no change in hPL or hCG levels in any group. Progesterone showed a significant fall after 40 min in the diabetic group and a less pronounced, although still significant fall after 80 min in the non-diabetic group. The oestriol levels increased significantly after 40 min in the diabetic group while no significant change was noted in the non-diabetic group. It is speculated that the effects in the diabetic women might be explained by a redistribution of the available placental 5-pregnenolone due to an increased fetal conversion into oestriol. This might be due to an increased sensitivity of the adrenal cortex of these foetuses to a supposed stimulatory effect of salbutamol.

Key words

Pregnancy - Diabetes - Human Chorionic Gonadotrophin - Human Placental Lactogen - Oestriol - Progesterone

      >