Three-Membered Ring Sesquiterpenoids with NGF-Potentiating Activity from the Roots of Valeriana fauriei

The structures of compounds 1∼3 reported in this paper,Planta Medica, 2006, 72: 373 – 375 , were incorrect. In this erratum, we report the corrected structures of compounds 1∼3 (Fig. [1]). Among them, compound 1 is isobicyclogermacrenal previously reported in the literature [1], while compounds 2 and 3 are new sesquiterpenoids. Their NMR data are assigned correctly in Table [1]1 based on 2D NMR spectra and the comparison of the spectral data with those reported in the literature for 1 [1].

¹ Tucker DJ, Southwell IA, Lowe RF, Russell MF, Brerton IM. ¹H and ¹³C-NMR assignments for the sesquiterpene aldehydes, lepidozenal and isobicyclogermacrenal, from Eucalyptus dawsonii. Magnetic in Chemistry 2007; 45: 1081 – 3

Fig. 1 Structures of compounds 1∼3.

Table 1  1H- and 13C-NMR data for compounds 1∼3 in CDCl3 (J values in parentheses). Position 1 2 3 δH a δC δH a δC 1 5.00 dd (11.0/5.5) 124.3 4.84 dd (11.0/5.5) 126.5 5.09 dd (11.0/5.5) 129.6 2 2.07 m2.16 m 27.7 1.82 m1.90 m 27.7 1.95 m2.05 m 27.2 3 2.74 m1.94 m 23.5 2.44 d (12.4)1.66 m 23.2 2.57 m1.76 m 22.7 4 142.9 142.3 142.0 5 6.24 d (9.5) 156.1 6.06 d (9.7) 156.7 6.14 d (9.5) 155.2 6 1.43 t (9.5/9.5) 29.8 1.13 dd (9.7/8.9) 29.7 1.22 t (9.5/9.5) 28.9 7 0.90 m 38.2 0.65 m 37.2 0.71 m 36.4 8 0.81 m1.78 m 23.4 0.56 m1.52 m 23.6 0.64 m1.63 m 23.2 9 1.96 m2.13 m 39.8 1.50 m2.30 m 34.3 1.66 m2.13 m 34.5 10 134.4 137.8 132.4 11 21.2 21.0 20.2 12 1.13 s 15.7 0.88 s 15.7 0.95 s 15.2 13 1.10 s 28.5 0.88 s 28.4 0.93 s 27.9 14 1.19 s 17.2 3.38 d (11.7)3.10 d (11.7) 58.1 3.89 s 60.2 15 9.20 s 194.3 8.89 s 194.2 9.03 s 192.9 OCOCH3 169.9 OCOCH 3 1.74 s 20.4