Ruthenium-Catalyzed Alkylation of Amines and Sulfonamides
with Alcohols

doi:10.1055/s-0028-1088182

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Synfacts 2009(5): 0541-0541
DOI: 10.1055/s-0028-1088182

Metal-Mediated Synthesis

Ruthenium-Catalyzed Alkylation of Amines and Sulfonamides with Alcohols

Contributor(s): Paul Knochel, Andrei Gavryushin
M. H. S. A. Hamid, C. L. Allen, G. W. Lamb, A. C. Maxwell, H. C. Maytum, A. J. A. Watson, J. M. J. Williams*
University of Bath and GlaxoSmithKline, Stevenage, UK

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Publikationsverlauf

Publikationsdatum:
22. April 2009 (online)

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Significance

This work describes a simple, highly versatile and practical method for the alkylation of primary and secondary amines as well as sulfonamides with various alcohols. A broad range of substrates can be used in this reaction that offers mostly excellent yields of products. This method is especially valuable for the modular synthesis of compounds libraries for pharmaceutical and agrochemical screening.