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Synfacts 2009(4): 0434-0434  
DOI: 10.1055/s-0028-1087832
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Tandem Synthesis of N-Fused Isoquinolines

Contributor(s): Paul Knochel, Andreas J. Wagner
A. K. Verma*, T. Kesharwani, J. Singh, V. Tandon, R. C. Larock*
University of Delhi, India and Iowa State University of Science and Technology, Ames, USA
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Publication History

Publication Date:
23 March 2009 (online)

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Significance

This work provides a facile and direct synthesis of substituted indolo- and pyrrolo[2,1-a]isoquinolines from ortho-halogenated aromatic alkynes and indole or pyrrole deriva-tives, respectively. Copper salts such as CuI or Cu(OAc)2 serve as catalyst with (hydroxymethyl)benzotriazole as ligand, affording the condensed aromatic products in good yields and excellent regioselectivity.