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Synfacts 2009(3): 0308-0308  
DOI: 10.1055/s-0028-1087705
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Fe/Cu-Cocatalyzed Arylation of Terminal Alkynes with Aryl Iodides

Contributor(s): Paul Knochel, Andrei Gavryushin
H. Huang, H. Jiang, K. Chen, H. Liu*
Shanghai Institute of Materia Medica, P. R. of China
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Publikationsdatum:
19. Februar 2009 (online)

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Significance

This is a practical protocol for the coupling of aryl iodides with terminal alkynes, ­using nontoxic and inexpensive Fe/Cu bimetallic catalysis. Various aryl and heteroaryl iodides react smoothly. Functional groups like cyano and nitro are well tolerated. This process can also be useful for industrial chemistry due to its versatility and the environmentally benign catalysts.