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Synfacts 2009(2): 0187-0187  
DOI: 10.1055/s-0028-1087507
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

In(III)-PyBox Complex Catalyzed Enantioselective Carbonyl-ene Reaction

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
J.-F. Zhao, H.-Y. Tsui, P.-J. Wu, J. Lu, T.-P. Loh*
Nanyang Technological University, Singapore
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Publication History

Publication Date:
22 January 2009 (online)

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Significance

In this paper, the authors have developed highly enantioselective and efficient carbonyl-ene reactions of ethyl glyoxylate catalyzed by the In(III)-PyBox complex. This methodology has several advantages, such as operational simplicity, mild reaction conditions, low catalyst loading (<5 mol%), and high enantioselectivities and yields.