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Synfacts 2009(1): 0048-0048
DOI: 10.1055/s-0028-1087442
DOI: 10.1055/s-0028-1087442
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Nickel-Catalyzed Intramolecular Arylcyanation of Alkenes
Y. Nakao*, S. Ebata, A. Yada, T. Hiyama*, M. Ikawa, S. Ogoshi*
Kyoto University and Osaka University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Dezember 2008 (online)
Significance
A broad range of intramolecular arylcyanation products were obtained through this nickel/Lewis acid catalyzed reaction, and in two cases, with high diastereoselectivities. Furthermore, important intermediates were unambiguously identified for clarifying the reaction mechanism, and asymmetric versions were also developed for two substrates to give products with high enantioselectivities.