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DOI: 10.1055/s-0028-1084825
Biotransformation of onopordopicrin, a sesquiterpene lactone, by Aspergillus niger
The biotransformation of sesquiterpene lactones from Aspergillus niger was studied previously [1]. In the course of our work related to compounds extracted from the aerial parts of Onopordon leptolopis, Asteraceae [2], we studied the biotransformation of onopordopicrin by Aspergillus niger which afforded 11α,13-dihydro-onopordopicrin (1), 11β,13-dihydro-onopordopicrin (2) and 3-hydroxy-11α,13-dihydro onopordopicrin (3). The last compound (3) again submitted to biotransformation by Aspergillus niger gave 3,14-dihydroxy –11α,13-dihydro-onopordopicrin (4). Onopordopicrin and related compounds were identified by 1H NMR, 13C NMR, mass spectroscopy and IR spectroscopy.
References: 1. Hoshimoto, T. et al. (2001) Heterocycles 54: 529–559.
2. Rustaiyan, A., et al. (1979) Phytochemistry 18: 883–884.