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Planta Med 2008; 74 - PG4
DOI: 10.1055/s-0028-1084757
DOI: 10.1055/s-0028-1084757
Biomimetic synthesis of polycyclic alkaloids from the Nitraria and Myrioneuron genus
Closely related polycyclic alkaloids have been isolated from different species of Nitraria (Zygophylaceae) and Myrioneuron (Rubiaceae). They feature an original lysine-derived metabolism with condensation of reactive C5 units as a pivotal scheme. Recent biomimetic investigations towards the total synthesis of alkaloids such as tangutorine [1] and myrioneurinol [2] are presented.
References: 1. Duan, J.A. et al. (1999) Tetrahedron Lett., 40:2593–2596.
2. Pham, V.C. et al. (2006) Tetrahedron, 63:11244–11249.