This presentation describes new discoveries from our investigations into bioactive
metabolites from Australian marine invertebrates and microbes, including the;
Acremolides [1]: a new class of lipodepsipeptides. This account also describes a parallel study
that succeeded in optimizing and broadening application of the Marfey's method for
amino acid analysis [2].
Reveromycins [3]: a rare class of polyketide spiroacetals with potential application in cancer,
arthritis and osteoporosis, this study revealed new structures that underscored the
chemistry and biology of reveromycins.
Trachycladindoles [4]: a new class of indolo-dihydroimidazoles, with selective activity against human
cancer cell lines. Structural studies extended to consideration of conformational
barriers, stability and SAR.
References: 1. Ratnayake, R. et. al. (2008)J. Nat. Prod. 71:403–408
2. Fremlin, LJ. et al. (2008) unpublished results
3. Capon, RJ. et al. (2008) unpublished results
4. Capon, RJ. et al. (2008) Org. Biol. Chem. asap
