Planta Med 2008; 74 - SL96
DOI: 10.1055/s-0028-1083976

Australian marine biodiscovery

RJ Capon 1
  • 1University of Queensland, Institute for Molecular Bioscience, Carmody Rd, St Lucia, QLD 4072, Australia

This presentation describes new discoveries from our investigations into bioactive metabolites from Australian marine invertebrates and microbes, including the;

Acremolides [1]: a new class of lipodepsipeptides. This account also describes a parallel study that succeeded in optimizing and broadening application of the Marfey's method for amino acid analysis [2].

Reveromycins [3]: a rare class of polyketide spiroacetals with potential application in cancer, arthritis and osteoporosis, this study revealed new structures that underscored the chemistry and biology of reveromycins.

Trachycladindoles [4]: a new class of indolo-dihydroimidazoles, with selective activity against human cancer cell lines. Structural studies extended to consideration of conformational barriers, stability and SAR.

References: 1. Ratnayake, R. et. al. (2008)J. Nat. Prod. 71:403–408

2. Fremlin, LJ. et al. (2008) unpublished results

3. Capon, RJ. et al. (2008) unpublished results

4. Capon, RJ. et al. (2008) Org. Biol. Chem. asap