Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2008(11): 1170-1170
DOI: 10.1055/s-0028-1083434
DOI: 10.1055/s-0028-1083434
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Synthesis of Dienyl Alcohols
M. Naodovic, G. Xia, H. Yamamoto*
The University of Chicago, USA
Further Information
Publication History
Publication Date:
23 October 2008 (online)

Significance
Addition reactions with allenyl metal reagents often suffer from regioselectivity issues and lead to isomeric mixtures. Although the reaction’s efficiency could be improved, the chiral chromium catalyst TBOxCrCl is unique in allowing to obtain single products in high enantioselectivity. Moreover, it avoids drawbacks associated with other methods (i.e., low regioselectivity, toxic reagents, lengthy starting material preparation).