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DOI: 10.1055/s-0028-1083395
Solvent-Free Organic Transformations with Amberlite IRA900F
F. Fringuelli*, D. Lanari, F. Pizzo, L. Vaccaro*
Università di Perugia, Italy
Publication History
Publication Date:
23 October 2008 (online)

Significance
A variety of organic transformations with Amberlite IRA900F (Amb-F) as a metal-free catalyst for the activation of Si-N and Si-O bonds and a mild base under solvent-free conditions is described. Thus, Amb-F was applied to (1) the [3+2] cycloaddition of nitroalkenes 1 with TMSN3 2, (2) the 1,3-dipolar cycloaddition of aryl nitriles 4 and 2, (3) the Michael addition of 2 to α,β-unsaturated carboxylic acids and esters 6, (4) the Michael addition of ketene silyl acetal 9 to nitroalkenes 8, and (5) the Michael addition of ethyl nitroacetate 11 onto 8 under solvent-free conditions, to give the corresponding adducts in 70-96% yield.