Klin Monbl Augenheilkd
DOI: 10.1055/a-2730-1136
Der interessante Fall

Recurrent Vitreous Haemorrhage Due to Atypical Branch Retinal Vein Occlusion in a Patient with HLA-B51 Positivity and Heterozygous PAI-1 4G/5G Polymorphism

Rezidivierende Glaskörperblutung aufgrund atypischer Venenastthrombose bei HLA-B51-Positivität und heterozygotem PAI-1-4G/5G-Polymorphismus

Authors

  • Stefanie Hartmann

    1   Department of Ophthalmology, Cantonal Hospital St. Gallen, Switzerland
  • Margarita G. Todorova

    1   Department of Ophthalmology, Cantonal Hospital St. Gallen, Switzerland
    2   Department of Ophthalmology, University Hospital Zurich, Switzerland

Background

Branch retinal vein occlusion (BRVO) is a common retinal vascular disorder typically associated with systemic risk factors such as hypertension, diabetes mellitus, or hyperlipidaemia. In atypical or recurrent cases in younger patients, less common aetiologies, including genetic or inflammatory factors, must be considered [1].



Publication History

Received: 24 August 2025

Accepted: 20 October 2025

Article published online:
02 December 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References

  • 1 Parodi MB, Bandello F. Branch retinal vein occlusion: classification and treatment. Ophthalmologica 2009; 223: 298-305
  • 2 Bucan K, Plestina Borjan I, Bucan I. et al. Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report. Case Rep Ophthalmol 2018; 9: 248-253
  • 3 Gori AM, Marcucci R, Fatini C. et al. Impaired fibrinolysis in retinal vein occlusion: a role for genetic determinants of PAI-1 levels. Thromb Haemost 2004; 92: 54-60
  • 4 Vaughan DE. PAI-1 and atherothrombosis. J Thromb Haemost 2005; 3: 1879-1883
  • 5 Russo PD, Damante G, Pasca S. et al. Thrombophilic mutations as risk factor for retinal vein occlusion: a case-control study. Clin Appl Thromb Hemost 2015; 21: 373-377
  • 6 de Menthon M, Lavalley MP, Maldini C. et al. HLA-B51/B5 and the risk of Behcetʼs disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum 2009; 61: 1287-1296
  • 7 Ji KB, Hu Z, Zhang QL. et al. Retinal microvasculature features in patients with Behcetʼs disease: a systematic review and meta-analysis. Sci Rep 2022; 12: 752