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Semin Respir Crit Care Med
DOI: 10.1055/a-2724-5501
DOI: 10.1055/a-2724-5501
Review Article
Genetics and Social Determinants of Health as Drivers of Epidemiologic Variation in Sarcoidosis
Authors
Funding Information J.O. was supported by a Path to K award from the Ohio State University College of Medicine Office of Research and the Clinical and Translational Science Institute (CTSI) through the Richard P. & Marie R. Bremer Medical Research Fund and William H. Davis Endowment for Basic Medical Research. M.S. was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number K23HL148527. The content is solely the responsibility of the authors and does not reflect the views of the Davis/Bremer Research Fund, the CTSI, the Ohio State University Medical Center, or the National Heart, Lung, and Blood Institute of the National Institutes of Health.
Abstract
Sarcoidosis is a disease with high morbidity that has variable epidemiology based on genetics and sociodemographic factors. The etiology of this variability remains incompletely understood. This narrative review describes how genetics, social determinants of health, and the interactions between them may contribute to the differences in epidemiology and health outcomes observed in different patient groups with sarcoidosis.
Keywords
sarcoidosis - epidemiology - social determinants of health - genetics - pulmonary medicine - health disparitiesPublication History
Received: 29 July 2025
Accepted: 16 October 2025
Accepted Manuscript online:
23 October 2025
Article published online:
03 November 2025
© 2025. Thieme. All rights reserved.
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