Lasmiditan in Migraine Management: An Advanced Review of Its Pharmacological Paradigm, Clinical Applications, Safety Considerations, Drug Interaction Spectrum, and Regulatory Approval

Abstract

Purpose

This review offers an in-depth evaluation of Lasmiditan, a novel and selective 5-HT1F receptor agonist, representing a significant breakthrough in migraine pharmacotherapy. Unlike existing reviews, this article consolidates all critical aspects of Lasmiditan into a single, authoritative source encompassing both extensive literature analysis and original findings from our laboratory to provide researchers and clinicians with streamlined access to essential data and minimize the need for exhaustive literature searches.

Main Findings

The review provides a comprehensive assessment of Lasmiditan, highlighting its physicochemical properties, pharmacological profile, mechanism of action, clinical efficacy and safety, drug interactions, and emerging insights from cell line studies. Lasmiditan’s solubility influences its bioavailability and efficacy. It acts centrally without vascular constriction, unlike traditional therapies. Clinical trials confirm its rapid, effective migraine relief with mild side effects. Minimal drug interactions support its use in polypharmacy. Cell studies reveal its receptor activity and transport mechanisms, enhancing therapeutic understanding.

Conclusion

Lasmiditan represents a groundbreaking addition to migraine therapeutics, providing a targeted, non-vasoconstrictive alternative. Its safety, tolerability, and efficacy make it a strong alternative for patients unsuitable for traditional treatments, with ongoing research likely to expand its clinical relevance.

Keywords

5-HT_1F Receptor - Clinical efficacy - Migraine - Lasmiditan - Non-vasoconstriction - Non-Triptan Therapy

Publication History

Received: 01 July 2025

Accepted after revision: 24 August 2025

Article published online:
24 September 2025

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