Desaturation of Amides via Bismuth Photocatalysis

Abstract

Bismuth redox catalysis has been intensively developed in recent years, enabling diverse transformations that were previously thought to be achievable only through transition metal catalysis. In this study, we present the desaturation of amides to generate the enamides, an important structural motif in pharmaceuticals, via bismuth photocatalysis. The protocol involves a combination of unique mechanistic steps recently uncovered for bismuth thus allowing for the translation of a canonical transition metal–mediated transformation into a main group–based catalytic system.

Keywords

Bismuth - Low-valent bismuth - Bismuth redox catalysis - Bismuth photocatalysis - Desaturation - Amides

Publikationsverlauf

Eingereicht: 23. Juni 2025

Angenommen nach Revision: 18. August 2025

Accepted Manuscript online:
18. August 2025

Artikel online veröffentlicht:
02. Oktober 2025

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