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DOI: 10.1055/a-2676-7455
Investigating Symptomatic Vitreous Opacities: An Online Survey and Field of View Reconstruction
Untersuchung symptomatischer Glaskörpertrübungen: eine Online-Umfrage und SichtfeldrekonstruktionAuthors
This survey was sponsored by the Association for Research in Precision Mechanics, Optics and Medical Technology (F.O.M.) and SPECTARIS – the German industry association for Optics, Photonics, Analytical and Medical Technologies. It was linked to the F.O.M. research project “XFloater” (funding code 21011 N) funded by the German Federal Ministry for Economic Affairs and Climate Action (BMWK) within the Promotion of Joint Industrial Research Programme (IGF) due to a decision of the German Bundestag. Publication funded by zukunft.niedersachsen, the joint science funding program of the Lower Saxony Ministry of Science and Culture and the Volkswagen Foundation.

Abstract
Background Symptomatic vitreous opacities (SVO) are a condition that can significantly affect patientsʼ quality of life. This online survey aims to contribute to the scientific understanding of symptomatic vitreous opacities, by investigating the subjective burden and individual perception of floaters, using a novel tool for field of view reconstruction. In addition, correlations with demographic data and refractive status will be analysed to identify patterns and potential influencing factors.
Methods We introduce a VO-related online survey covering patient education, experience with floaters and treatment, refraction error and eye diseases, quality of life, and a new sketching tool to simulate the individual field of view with VO. The data were collected between August 2022 and November 2023 and are analysed for correlations; participantsʼ answers are compared to the sketching tool results. We used linear regression with gradient descent to test whether a subjective suffering index from the questionnaire can be matched with an objective suffering index from the new sketching tool.
Results A total of 1502 people participated in the survey, of whom, 1384 reconstructed their field of view by positioning a total of 10,571 VO. There was no robust correlation between the sketched floaters and the subjective degree of suffering. Translucent VO types are more frequent in younger attendees. The dataset shows a higher prevalence of myopic participants and a lower prevalence of hyperopes with VO compared to global data.
Conclusion We were able to collect the largest dataset to date quantifying individual experience with floaters. As evidenced by the large number of participants with SVO and individual remarks on their psychological burden, greater effort is needed to improve the care for floater patients.
Zusammenfassung
Hintergrund Symptomatische Glaskörpertrübungen können die Lebensqualität der Betroffenen erheblich beeinträchtigen. Diese Online-Umfrage soll zum wissenschaftlichen Verständnis symptomatischer Glaskörpertrübungen beitragen, indem die subjektive Belastung und die individuelle Wahrnehmung von Floatern mithilfe eines neuartigen Tools zur Rekonstruktion des Gesichtsfeldes ermittelt werden. Darüber hinaus werden Korrelationen zu demografischen Daten und dem Refraktionsstatus analysiert, um potenzielle Einflussfaktoren zu identifizieren.
Methoden Die hier präsentierte Online-Umfrage zum Thema Glaskörpertrübung umfasst Zusammenhänge zu Patientenaufklärung, Erfahrungen mit Floatern und Behandlung, Refraktionsfehlern und Augenerkrankungen, Lebensqualität und einem neuen Skizzierwerkzeug zur Simulation des individuellen Gesichtsfeldes mit VO. Die zwischen August 2022 und November 2023 gesammelten Daten wurden auf Korrelationen untersucht und die Antworten der Teilnehmer mit den Ergebnissen des Skizzierwerkzeug verglichen. Wir haben eine lineare Regression mit Gradientenabstieg verwendet, um zu prüfen, ob ein subjektiver Leidensindex aus dem Fragebogen mit einem objektiven Leidensindex aus dem neuen Skizzierwerkzeug übereinstimmen kann.
Ergebnisse Insgesamt nahmen 1502 Personen an der Umfrage teil, von denen 1384 ihr Sichtfeld durch Positionierung von insgesamt 10 571 Floater rekonstruierten. Es gab keine robuste Korrelation zwischen den skizzierten Floatern und dem subjektiven Leidensdruck. Transluzente Trübungen treten häufiger bei jüngeren Teilnehmern auf. Der Datensatz zeigt eine höhere Prävalenz von myopen und eine geringere Prävalenz von hyperopen Teilnehmern mit Floatern im Vergleich zu globalen Daten.
Schlussfolgerung Wir konnten den bisher größten uns bekannten Datensatz zur Quantifizierung individueller Erfahrungen mit Glaskörpertrübungen erheben. Wie die große Zahl der Teilnehmer mit symptomatischen Glaskörpertrübungen und die individuellen Aussagen zur psychischen Belastung zeigen, sind weitere Anstrengungen notwendig, um die Versorgung von Floater-Patienten zu verbessern.
Already known:
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The morphologies of vitreous floaters are rarely differentiated in the literature.
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Individual assessment of severity remains a difficult task.
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The correlation between myopia and vitreous opacities is widely recognized, but it has not been compared against global data on refractive status.
Newly described:
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This work proposes a new method to measure individual suffering using the reconstruction of the personal visual field with floaters.
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Floater morphology appears to be age dependent. Future and current floater type dependent treatments are therefore targeting a different generation of patients.
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Compared to global public data, our dataset of participants affected by floaters shows a higher prevalence of myopia and a lower prevalence of hyperopia. As myopia increases in the global population, the number of people with symptomatic vitreous opacities is also likely to increase.
Publication History
Received: 21 May 2025
Accepted: 03 July 2025
Accepted Manuscript online:
05 August 2025
Article published online:
15 October 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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References
- 1 Whitley W, Early AD, Gerson JD. et al. Best Practice On Referring Patients With Symptomatic Vitreous Opacities. Cataract Refract Surg Today 2022. https://retinatoday.com/articles/2022-may-june-supplement/best-practices-on-referring-patients-with-symptomatic-vitreous-opacities Stand: 03.04.2024
- 2 Roufail ED, Polkinghorne P. Vitreous floaters. Compr Ophthalmol Update 2006; 7: 171-177
- 3 Ponsioen TL, Hooymans JMM, Los LI. Remodelling of the human vitreous and vitreoretinal interface–a dynamic process. Prog Retin Eye Res 2010; 29: 580-595
- 4 Scott JE. The chemical morphology of the vitreous. Eye (Lond) 1992; 6: 553-555
- 5 Milston R, Madigan MC, Sebag J. Vitreous floaters: Etiology, diagnostics, and management. Surv Ophthalmol 2016; 61: 211-227
- 6 Gishti O, van den Nieuwenhof R, Verhoekx J. et al. Symptoms related to posterior vitreous detachment and the risk of developing retinal tears: a systematic review. Acta Ophthalmol 2019; 97: 347-352
- 7 Dayan MR, Jayamanne DGR, Andrews RM. et al. Flashes and floaters as predictors of vitreoretinal pathology: is follow-up necessary for posterior vitreous detachment?. Eye (Lond) 1996; 10: 456-458
- 8 Webb BF, Webb JR, Schroeder MC. et al. Prevalence of vitreous floaters in a community sample of smartphone users. Int J Ophthalmol 2013; 6: 402-405
- 9 Sebag J. Vitreous and Vision Degrading Myodesopsia. Prog Retin Eye Res 2020; 79: 100847
- 10 Serpetopoulos CN, Korakitis RA. An optical explanation of the entoptic phenomenon of “clouds” in posterior vitreous detachment. Ophthalmic Physiol Opt 1998; 18: 446-451
- 11 Harmer SW, Luff AJ, Gini G. Optical Scattering from Vitreous Floaters. Bioelectromagnetics 2022; 43: 90-105
- 12 Senra H, Ali Z, Aslam T. et al. Psychological implications of vitreous opacities – A systematic review. J Psychosom Res 2022; 154: 110729
- 13 Schiff WM, Chang S, Mandava N. et al. Pars plana vitrectomy for persistent, visually significant vitreous opacities. Retina 2000; 20: 591-596
- 14 Kim YK, Moon SY, Yim KM. et al. Psychological Distress in Patients with Symptomatic Vitreous Floaters. J Ophthalmol 2017; 2017: 1-9
- 15 García BG, Orduna Magán C, Alvarez-Peregrina C. et al. Nd : YAG laser vitreolysis and health-related quality of life in patients with symptomatic vitreous floaters. Eur J Ophthalmol 2022; 32: 1143-1148
- 16 Wu RH. Pars plana vitrectomy relieves the depression in patients with symptomatic vitreous floaters. Int J Ophthalmol 2020; 13: 412-416
- 17 Mamou J, Wa CA, Yee KMP. et al. Ultrasound-based quantification of vitreous floaters correlates with contrast sensitivity and quality of life. Invest Ophthalmol Vis Sci 2015; 56: 1611-1617
- 18 Sebag J, Yee KMP, Wa CA. et al. Vitrectomy for floaters: prospective efficacy analyses and retrospective safety profile. Retina 2014; 34: 1062-1068
- 19 West SK, Rubin GS, Broman AT. et al. How Does Visual Impairment Affect Performance on Tasks of Everyday Life? The SEE Project. Salisbury Eye Evaluation. Arch Ophthalmol 2002; 120: 774-780
- 20 Dysager DD, Koren SF, Grauslund J. et al. Efficacy and Safety of Pars Plana Vitrectomy for Primary Symptomatic Floaters: A Systematic Review with Meta-Analyses. Ophthalmol Ther 2022; 11: 2225-2242
- 21 Jackson TL, Donachie PHJ, Sparrow JM. et al. United Kingdom National Ophthalmology Database Study of Vitreoretinal Surgery: Report 1; Case mix, complications, and cataract. Eye (Lond) 2013; 27: 644-651
- 22 Fink S, Kumar JB, Cunningham MA. Small-Gauge Pars Plana Vitrectomy for Visually Significant Vitreous Floaters. J Vitreoretin Dis 2021; 5: 247-250
- 23 Hahn P, Schneider EW, Tabandeh H. et al. Reported Complications Following Laser Vitreolysis. JAMA Ophthalmol 2017; 135: 973-976
- 24 Lin T, Li T, Zhang X. et al. The Efficacy and Safety of YAG Laser Vitreolysis for Symptomatic Vitreous Floaters of Complete PVD or Non-PVD. Ophthalmol Ther 2022; 11: 201-214
- 25 Katsanos A, Tsaldari N, Gorgoli K. et al. Safety and Efficacy of YAG Laser Vitreolysis for the Treatment of Vitreous Floaters: An Overview. Adv Ther 2020; 37: 1319-1327
- 26 Su D, Shah CP, Hsu J. Laser vitreolysis for symptomatic floaters is not yet ready for widespread adoption. Surv Ophthalmol 2020; 65: 589-591
- 27 Tassignon MJ, Ní Dhubhghaill S, Ruiz Hidalgo I. et al. Subjective Grading of Subclinical Vitreous Floaters. Asia Pac J Ophthalmol (Phila) 2016; 5: 104-109
- 28 van Overdam KA. Symptoms and Findings Predictive for the Development of New Retinal Breaks. Arch Ophthalmol 2005; 123: 479-484
- 29 Tanner V, Harle D, Tan J. et al. Acute posterior vitreous detachment: The predictive value of vitreous pigment and symptomatology. Evidence-Based Eye Care 2001; 2: 74-75
- 30 Hashemi H, Fotouhi A, Yekta A. et al. Global and regional estimates of prevalence of refractive errors: Systematic review and meta-analysis. J Curr Ophthalmol 2018; 30: 3-22
- 31 Holden BA, Fricke TR, Wilson DA. et al. Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology 2016; 123: 1036-1042
- 32 Long E, Wu X, Ding X. et al. Real-world big data demonstrates prevalence trends and developmental patterns of myopia in China: a retrospective, multicenter study. Ann Transl Med 2021; 9: 554
- 33 Delaney YM, Oyinloye A, Benjamin L. Nd : YAG vitreolysis and pars plana vitrectomy: surgical treatment for vitreous floaters. Eye (Lond) 2002; 16: 21-26
- 34 Shah CP, Heier JS. YAG Laser Vitreolysis vs. Sham YAG Vitreolysis for Symptomatic Vitreous Floaters. JAMA Ophthalmol 2017; 135: 918-923
- 35 Luo J, An X, Kuang Y. Efficacy and safety of yttrium-aluminium garnet (YAG) laser vitreolysis for vitreous floaters. J Int Med Res 2018; 46: 4465-4471
- 36 Kasetty VM, Monsalve PF, Sethi D. et al. Cataract progression after primary pars plana vitrectomy for uncomplicated rhegmatogenous retinal detachments in young adults. Int J Retin Vitr 2024; 10: 1-7
- 37 Yee KM, Wa CA, Nguyen JH. et al. Reducing post-vitrectomy cataracts. Invest Ophthalmol Vis Sci 2014; 55: ARVO E-Abstract 2205 Accessed April 02, 2025 at: https://iovs.arvojournals.org/article.aspx?articleid=2267525
- 38 Dave V, Pathengay A, Schwartz SG. et al. Endophthalmitis following pars plana vitrectomy: a literature review of incidence, causative organisms, and treatment outcomes. Clin Ophthalmol 2014; 8: 2183
- 39 Bhende M, Raman R, Jain M. et al. Incidence, microbiology, and outcomes of endophthalmitis after 111,876 pars plana vitrectomies at a single, tertiary eye care hospital. PLoS One 2018; 13: e0191173
- 40 AlBloushi B, Mura M, Khandekar R. et al. Endophthalmitis Post Pars Plana Vitrectomy Surgery. Middle East Afr J Ophthalmol 2021; 28: 1-5
- 41 Boneva SK, Nguyen JH, Gui W. et al. Recurrent Floaters after Limited Vitrectomy for Vision Degrading Myodesopsia. Retina 2023; 43: 1114-1121
- 42 Schulz-Key S, Carlsson JO, Crafoord S. Longterm follow-up of pars plana vitrectomy for vitreous floaters: Complications, outcomes and patient satisfaction. Acta Ophthalmol 2011; 89: 159-165
- 43 Sebag J, Yee KMP, Nguyen JH. et al. Long-Term Safety and Efficacy of Limited Vitrectomy for Vision Degrading Vitreopathy Resulting from Vitreous Floaters. Ophthalmol Retina 2018; 2: 881-887
