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CC BY 4.0 · Pharmaceutical Fronts 2025; 07(03): e143-e157
DOI: 10.1055/a-2646-1097
DOI: 10.1055/a-2646-1097
Review Article
Recent Advances in Novel Modulators for Cardiac Myosin Disorders
Funding This work was supported by the National Science and Technology Major Project (Grant No. 2018ZX09711002-002-009), the National Natural Science Foundation of China (Grant No. 81703358), and the Science and Technology Commission of Shanghai Municipality (Grant Nos. 17431903900, 18QB1404200, 21S11908000, 22ZR1460300, 23DZ2292600).
Abstract
In advanced stages of heart disease, most cases are characterized by heart failure, where the heart's systolic and diastolic functions are weakened, and then it cannot meet the body's normal oxygen demands. The contraction of the heart, at the molecular level, involves the interaction between thick filaments (primarily composed of myosin) and thin filaments (primarily composed of actin), where adenosine triphosphate is used as an energy source to generate contraction force. In view of this, cardiac myosin may be a crucial target for the regulation of heart-related diseases. In 2022, mavacamten was approved by the Food and Drug Administration as a first-in-class myosin modulator for the treatment of obstructive hypertrophic cardiomyopathy. At the same time, there is continuing evidence that indicates cardiac myosin modulators as potential agents for the treatment of a variety of cardiac conditions. This review summarizes the current discovery, design, and indication of cardiac myosin modulators to provide valuable insights for further drug development in related fields.
Publication History
Received: 05 November 2024
Accepted: 30 June 2025
Article published online:
18 August 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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