Synlett, Table of Contents Synlett 2025; 36(18): 3053-3056DOI: 10.1055/a-2616-5579 Letter Deuterated Oxazoloisoindolinones via Photocatalytic Deoxygenative Cyclization of Amino Acid Derivatives Authors Author Affiliations Chuanli Wei 1 School of Chemistry, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399) 2 Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China (Ringgold ID: RIN12589) Yan Geng 1 School of Chemistry, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399) Yue Ma 1 School of Chemistry, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399) Hanlin Yang 1 School of Chemistry, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399) 2 Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China (Ringgold ID: RIN12589) Songjie Yu 1 School of Chemistry, Dalian University of Technology, Dalian, China (Ringgold ID: RIN12399) 2 Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan, China (Ringgold ID: RIN12589) Recommend Article Abstract Buy Article(opens in new window) All articles of this category(opens in new window) Abstract A stereoselective synthesis of deuterated oxazoloisoindolinones using D2O was achieved through photocatalytic deoxygenation of readily available N-phthalimide amino acids, followed by an intramolecular 5-endo-trig cyclization. This protocol provides an efficient access to a broad array of deuterium-labeled N,O-heterobicycles with excellent deuterium incorporation. Keywords KeywordsAmino acid - Photocatalytic deoxygenation - Cyclization - Deuterium incorporation - Oxazoloisoindolinone Full Text References References 1a Sulkowski TS. US Patent US 3336306A. 1967 15 1b Nagase T, Iino T, Sato Y, Nishimura T, Eiki J. Patent WO 2001014386. 2001 1c Oares J, Raimundo L, Pereira NAL. et al. Oncotarget 2016; 7: 4326 1d Soares J, Espadinha M, Raimundo L. et al. Mol Oncol 2017; 11: 612 1e Barcherini V, Almeida J, Lopes EA. et al. ChemMedChem 2021; 16: 250 2 Iino T, Sato Y, Nishimura T, Banba M, Eiki J, Nagase T. Patent JP2002255967. 2002 11. 3 Hatayama S, Hayashi K, Honma M, Takahashi I. Patent JP 2002220338. 2002 4a Cho CS, Chu DY, Lee DY. et al. Synth Commun 1997; 27: 4141 4b Ali MTM, Husin ZM, Macabeo APG. ACS Omega 2021; 6: 24614 5 Alladoum J, Vrancken E, Mangeney P, Roland S, Kadouri-Puchot C. 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