Open Access
CC BY 4.0 · Pharmaceutical Fronts 2025; 07(02): e65-e76
DOI: 10.1055/a-2550-9141
Review Article

Progress in Continuous-flow Oxidation of Aromatic Hydrocarbons

Kaikai Zhang
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Weike Su
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
2   Zhejiang Governor Triangle Biomedical Industrial Technology Research Park, Huzhou, People's Republic of China
› Institutsangaben

Funding None.
Preview

Abstract

Aromatic alcohols, aromatic aldehydes, and aromatic acids are usually synthesized by oxidation of the corresponding aromatic compounds and can be used as intermediates for the synthesis of pharmaceuticals, dyes, plasticizers, and fragrances. However, implementing these oxidations in conventional batch reactors, especially on larger scales, is often associated with severe safety risks and process challenges. The potential of explosion propagation within the reactor can be reduced using continuous-flow technology, which can eliminate or alleviate these safety hazards by reducing the size of the reactor and the size of the channel. In this paper, the research progress on aromatic hydrocarbon catalytic oxidation reactions using continuous-flow technology, as well as various catalytic systems and the corresponding selectivity, is reviewed. The translation of aerobic oxidation from batch oxidation to continuous-flow processes, including process intensification and equipment study, has also been discussed.



Publikationsverlauf

Eingereicht: 10. Oktober 2024

Angenommen: 04. März 2025

Artikel online veröffentlicht:
22. April 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany