Microvascular Abnormalities, Inner Retina Thinning and Sectorial Optic Atrophy after Low-dose Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: A Case Report

Angelica Rizzato; Helena Giannakaki-Zimmermann; Florian Weisskopf; Katja Hatz-Wurziger

doi:10.1055/a-2542-4073

Klinische Monatsblätter für Augenheilkunde, Table of Contents

CC BY 4.0 · Klin Monbl Augenheilkd 2025; 242(04): 421-425
DOI: 10.1055/a-2542-4073

Der interessante Fall

Microvascular Abnormalities, Inner Retina Thinning and Sectorial Optic Atrophy after Low-dose Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: A Case Report

Mikrovaskuläre Anomalien, Ausdünnung der inneren Netzhaut und sektorielle Optikusatrophie nach niedrig dosierter stereotaktischer Strahlentherapie bei neovaskulärer altersbedingter Makuladegeneration: Ein Fallbericht

Angelica Rizzato

¹Vista Klinik AG, Binningen, Switzerland

²Eye Clinic, University Hospital Basel, Basel, Switzerland

,

Helena Giannakaki-Zimmermann

¹Vista Klinik AG, Binningen, Switzerland

,

Florian Weisskopf

¹Vista Klinik AG, Binningen, Switzerland

,

Katja Hatz-Wurziger

¹Vista Klinik AG, Binningen, Switzerland

³Medical Faculty, University Hospital Basel, Basel, Switzerland

› Author Affiliations

Abstract

Full Text

References

References
1 Gertner M, Pavlakovic G, Webster K. et al. Stereotactic targeting and dose verification for age‐related macular degeneration. Med Phys 2010; 37: 600-606
2 Evans JR, Igwe C, Jackson TL. et al. Radiotherapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev 2020; (08) CD004004
3 Jackson TL, Chakravarthy U, Kaiser PK. et al. Stereotactic radiotherapy for neovascular age-related macular degeneration: 52-week safety and efficacy results of the INTREPID study. Ophthalmology 2013; 120: 1893-1900
4 Jackson TL, Chakravarthy U, Slakter JS. et al. Stereotactic radiotherapy for neovascular age-related macular degeneration: year 2 results of the INTREPID study. Ophthalmology 2015; 122: 138-145
5 Hatz K, Zimmermann F, Kardamakis D. et al. Low-energy stereotactic radiotherapy for treatment of exudative age-related macular degeneration in a treat-and-extend regimen. Ophthalmic Surg Lasers Imaging Retina 2018; 49: 86-93
6 Freiberg FJ, Michels S, Muldrew A. et al. Microvascular abnormalities secondary to radiation therapy in neovascular age-related macular degeneration: findings from the INTREPID clinical trial. Br J Ophthalmol 2019; 103: 469-474
7 Chen K, Browne AW. Radiation retinopathy. Curr Ophthalmol Rep 2023; 11: 49-56
8 Torkashvand A, Riazi-Esfahani H, Ghassemi F. et al. Evaluation of radiation maculopathy after treatment of choroidal melanoma with ruthenium-106 using optical coherence tomography angiography. BMC Ophthalmol 2021; 21: 385
9 Hatz K, Zimmermann F, Lazaridis E. et al. Microvascular abnormalities and long-term efficacy after stereotactic radiotherapy under continued intravitreal anti-VEGF treatment for neovascular AMD. Br J Ophthalmol 2022; 106: 415-421
10 Tamplin MR, Browne AW, Lin J. et al. Radiation effects on retinal layers revealed by OCT, OCT-A, and perimetry as a function of dose and time from treatment. Sci Rep 2024; 14: 3380
11 Ataídes FG, Silva SFBR, Baldin JJCMC. Radiation-induced optic neuropathy: literature review. Neuroophthalmology 2020; 45: 172-180
12 Kanamori A, Catrinescu MM, Belisle JM. et al. Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy. Am J Pathol 2012; 181: 62-73