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CC BY 4.0 · Pharmaceutical Fronts 2025; 07(01): e1-e8
DOI: 10.1055/a-2523-2174
Review Article

Undeveloped Region in Target-Strategies and Potential in Antiviral Drug Discovery

Shaoqing Du
1   Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China
,
Xinyong Liu
1   Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China
,
Xueping Hu
2   Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, People's Republic of China
,
Peng Zhan
1   Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China
› Author Affiliations
Funding This work was supported by the National Natural Science Foundation of China (Grant Nos. 22208191, 22273049), the Development Plan for Youth Innovation Team of Shandong Province (Grant No. 2023KJ011), the Major Basic Research Project of Shandong Provincial Natural Science Foundation (Grant No. ZR2021ZD17), and the Science Foundation for Outstanding Young Scholars of Shandong Province (Grant No. ZR2020JQ31).
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Abstract

Drug resistance is a looming threat to global health security, undermining the effectiveness of current treatments and increasing treatment failures. To address this challenge, it is necessary to explore innovative strategies by identifying new binding mechanisms and targeting previously undeveloped therapeutic avenues. This paper reviewed the potential of leveraging undeveloped domains to combat drug resistance and proposes a range of methodologies to accurately identify those specific targets. There is also an extensive review of the challenges associated with targeting undeveloped areas and strategies to effectively address them. In this process, the application of artificial intelligence (AI) can effectively improve the efficiency of drug design, while appropriate attention should be paid to the physicochemical and drug-like properties of pharmaceutical compounds in the realm of drug discovery. Given the above, focusing on these undeveloped areas could provide a promising pathway to address drug resistance; however, achieving this objective necessitates sustained investigative efforts and inventive approaches.

Keywords

drug resistance - targeting undeveloped sites - antiviral drug design - target-based drug discovery


Publication History

Received: 29 September 2024

Accepted: 23 January 2025

Article published online:
24 February 2025

© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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