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Am J Perinatol 2025; 42(11): 1477-1484
DOI: 10.1055/a-2510-1543
Original Article

Enteral Feeding in Neonatal Hypoxic-Ischemic Encephalopathy

Authors

  • Helen Martinovski

    1   Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan

  • Luna Khanal

    1   Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan

  • Debra Kraft

    1   Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan

  • Girija Natarajan

    1   Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan
    2   Department of Pediatrics, Central Michigan University, Mount Pleasant, Michigan

Funding None.
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Abstract

Objective

This study aimed to describe feeding outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) and compare characteristics and outcomes in groups discharged home on oral, total/partial nasogastric, and gastrostomy tube feedings.

Study Design

This was a retrospective, single-center cohort study of infants diagnosed with moderate or severe HIE using standard criteria who underwent cooling from January 2017 to June 2022. Data were abstracted from hospital course as well as until 6 months follow-up. Statistical analysis included chi-square test and ANOVA with post hoc Bonferroni correction for between-group comparisons.

Results

Among 123 included infants, 95 (77%) fed orally, 11 (9%) required total/partial nasogastric feeds and 17 (14%) had gastrostomy tubes at discharge. A significantly greater proportion of infants with gastrostomy-tube feeds at discharge had intrapartum complications, Apgar scores <5 at 5 and 10 minutes, severe rather than moderate HIE, and seizures. They also had a longer hospital stay, prolonged respiratory support and intubated days, and delayed initiation of feeding. Infants discharged on nasogastric feeds all attained oral feeds at a median (IQR) duration of 54 (6–178) days follow-up. Among the 106 (86%) infants with follow-up data, the gastrostomy group had significantly lower median weight and head circumference centiles compared to the others. Criteria for gavage eligibility were met before discharge in 98 (80%) of the cohort; 42% stayed beyond this benchmark.

Conclusion

Earlier identification of eventual gastrostomy tube insertion as well as discharge home on nasogastric feedings may reduce duration of hospitalization in infants with HIE. Our data may provide insights to guide practice improvement for enteral feedings in this population.

Key Points

  • In neonatal encephalopathy, impaired oral feedings is common.

  • Antepartum complications and HIE severity are associated with gastrostomy insertion.

  • Discharge home on gavage feeds could shorten hospital stay.

Keywords

hypoxic-ischemic encephalopathy - enteral - feeding - gastrostomy - nasogastric

Authors' Contributions

Dr. Girija Natarajan conceptualized and designed the study, helped with data analysis, and critically reviewed and revised the manuscript.

Dr. Helen Martinovski designed the data collection spreadsheet, collected data, carried out initial data analysis, and drafted the initial manuscript.

Debra Kraft identified patient population, collected data, and critically reviewed the manuscript.

Dr. Luna Khanal collected data and critically reviewed the manuscript.




Publication History

Received: 01 August 2024

Accepted: 03 January 2025

Accepted Manuscript online:
06 January 2025

Article published online:
10 February 2025

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