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DOI: 10.1055/a-2264-8302
Synthesis of 3,4-Disubstituted Pyrroline Nitroxides Containing Diphenylphosphane or Diphenylphosphane Oxide Substituents
Financial support from the Hungarian National Research, Development and Innovation Office (NKFI K 137793) and Molecular Scale Biophysics Research Infrastructure Transnational Access (TNA-MOSBRI-2023-166) are greatly acknowledged.
Dedicated to the memory of Prof. Ferenc Fülöp
Abstract
(Methyl 4-(diphenylphosphoryl)-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylate-1-yl)oxydanyl was obtained as a key intermediate of the reaction starting from 3,4-dibromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxydanyl or (methyl 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylate-1-yl)oxidanyl. This key compound could be converted into an azido-specific Staudinger ligation-inducing spin label, amino- and thiol-specific spin label, or MITO-CP-like antiproliferative agent.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2264-8302.
- Supporting Information
Publikationsverlauf
Eingereicht: 09. Dezember 2023
Angenommen nach Revision: 08. Januar 2024
Accepted Manuscript online:
08. Februar 2024
Artikel online veröffentlicht:
01. März 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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