CC BY-NC-ND 4.0 · Klin Monbl Augenheilkd 2024; 241(04): 432-434
DOI: 10.1055/a-2244-6657
Der interessante Fall

The Importance of QuantiFERON Gold Plus Test for the Diagnosis of Presumed Ocular Tuberculosis

Die Bedeutung des QuantiFERON Gold Plus-Tests für die Diagnose der vermuteten Augentuberkulose
Francesca Bruzzone
1   Ophthalmology, Jules-Gonin Eye Hospital, University of Lausanne, Switzerland
,
Margherita Plebani
2   Pediatric Infectious Diseases and Vaccinology Unit, Department Women-Mother-Child, Lausanne University Hospital, CHUV, Lausanne, Switzerland
,
Aikaterini Koryllou
3   Unit of Pediatric Rheumatology, Immunology and Allergology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
,
Matthieu Perreau
4   Division of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland
,
Yan Guex-Crosier 
1   Ophthalmology, Jules-Gonin Eye Hospital, University of Lausanne, Switzerland
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Background

In 2021, the World Health Organization (WHO) estimated 10.6 million new cases of active tuberculosis (TB) [1]. A TB infection results from the inhalation of small droplets contaminated with Mycobacterium tuberculosis (Mtb). Within 4 to 12 weeks after inhalation, a local tissue response and, in some cases, a hematogenous dissemination of Mtb occurs. Although the lung is the primary site of infection and pulmonary TB can be easily diagnosed by chest X-ray, extrapulmonary manifestations are not uncommon. After primary infection, patients may completely clear the Mtb, develop TB disease, or enter a latent stage (latent tuberculosis infection, LTBI) [2]. Reactivation of TB may occur without systemic symptoms and in extrapulmonary localization. In LTBI and in some extrapulmonary reactivations, diagnosis relies on indirect methods that assess the presence of sensitized lymphocytes capable of releasing cytokines when stimulated by mycobacterial antigens [3].



Publication History

Received: 03 October 2023

Accepted: 20 November 2023

Article published online:
23 April 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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