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DOI: 10.1055/a-2176-1585
Cost-Effective and Scalable Synthesis of 4-Bromo-1,2-dimethyl-1H-imidazole: A Key Building Block for Bioactive Molecules
Autoren
Abstract
A cost-effective, scalable, high-yielding, and commercially viable synthesis of 4-bromo-1,2-dimethyl-1H-imidazole (1), an important building block to construct various bioactive molecules has been established. The main feature of this method includes the selection of appropriate starting material 1,2-dimethyl-1H-imidazole in which the existing issue of regioisomer formation is circumvented and the selective debromination is accomplished by using isopropyl magnesium chloride.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2176-1585.
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Publikationsverlauf
Eingereicht: 02. August 2023
Angenommen nach Revision: 08. September 2023
Accepted Manuscript online:
14. September 2023
Artikel online veröffentlicht:
18. Oktober 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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