Abstract
Efficient, practical syntheses of sorafenib and regorafenib have been achieved in
a manner that is free from the problems associated with previously reported methods.
The process involved preparation of 4-(4-aminophenoxy)-N-methylpicolinamide (sorafenib intermediate) and 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide (regorafenib intermediate) using only a single base and did not
require the use of an inert atmosphere. The reaction of intermediates with phenyl
4-chloro-3-(trifluoromethyl)phenyl carbamate, prepared using water-assisted synthesis
of carbamates, was used to install the main urea functionality in these molecules.
Key words
sorafenib - regorafenib - diphenyl carbonate - unsymmetrical urea - carbamate
