Die Rolle des Oxytocinsystems für die Entstehung der Depression

ZUSAMMENFASSUNG

Oxytocin erregte aufgrund seiner Rolle für das menschliche Sozialverhalten in den letzten Jahren vermehrt Aufmerksamkeit hinsichtlich der Erforschung der Ätiologie depressiver Erkrankungen. Aktuelle Forschungsergebnisse legen die Komplexität des Oxytocinsystems und sowohl pro- als auch antisoziale Effekte des Neuropeptids offen, weshalb seine Rolle für die Salienz sozialer Reize oder allgemeiner für allostatische Prozesse diskutiert wird. Diese Arbeit fasst Befunde zu den Zusammenhängen zwischen Oxytocin und belastenden Lebensereignissen sowie zwischen Oxytocin und der Verstärkung sozialer Interaktionen zusammen. Ausgehend von diesen Verknüpfungen des Oxytocinsystems mit dem körperlichen Stresssystem und dem Belohnungssystem stellt diese Arbeit einen Versuch dar, aktuelle Theorien zur Funktion von Oxytocin auf die Depression anzuwenden, um so eine Hypothese zur Rolle des Oxytocinsystems hinsichtlich des Ursprungs der biologischen und behavioralen Korrelate dieser Störung aufzustellen.

ABSTRACT

Oxytocin has attracted increased attention in recent years with regard to research on the etiology of depressive disorders due to its role in human social behavior. Recent research has revealed the complexity of the oxytocin system and both pro- as well as antisocial effects of the neuropeptide, thus its role in the salience of social stimuli or more generally in allostatic processes is debated. This paper summarizes findings on the links between oxytocin and stressful life events as well as between oxytocin and reinforcement of social interactions. Based on these linkages of the oxytocin system with the physical stress system and the reward system, this work represents an attempt to apply current theories on the oxytocin system to depression to hypothesize the role of the oxytocin system with respect to the origin of the biological and behavioral correlates of this disorder.

Schlüsselwörter

Stress - Oxytocin - Bindung - Social-Salience - allostatische Theorie

Key words

Stress - oxytocin - relationship - social salience - allostatic theory

^* Beide Autoren trugen gleichermaßen zur Entstehung dieses Manuskripts bei.

Publication History

Article published online:
03 March 2023

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