Synthesis of α-Sulfoximino Tetrazoles via Azido-Ugi Four-Component Reaction

The sulfoximine-based tetrazoles have been synthesized via azido-Ugi four-component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 °C in the presence of InCl₃. Replacement of sulfoximines with sulfonimidamides (SIA) has delivered the corresponding SIA-based tetrazole. Interestingly, SIA also acts as a surrogate amine to furnish the corresponding aminotetrazole as a by-product.

Key words

sulfoximines - sulfonimidamides - Ugi reaction - tetrazoles - isocyanides

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