Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp³)–H Amidation for the Synthesis of Isoindolinones

Abstract

The synthesis of N-unprotected isoindolinones via rhodium(III)-catalyzed intramolecular C(sp³)–H amidation of various 2-methyl-N-substituted benzamides is developed. This protocol employs a free amino acid l-alanine as a ligand, which could significantly increase the reactivity of rhodium catalyst.

Key words

rhodium(III) catalyst - C(sp³)–H amidation - isoindolinones - N-substituted benzamides - synthetic methods

• References

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