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DOI: 10.1055/a-1866-4653
Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst
Authors
The authors thank the Data Center of Management Science, National Natural Science Foundation of China - Peking University (NNSFC, Grant No. 21272153), and also the Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences for financial support.
Abstract
Monofluorinated bis-heterocyclic spirocycles: functionalized ethyl 9-fluoro-8-methyl-1,4-dioxo-2,3,6,10-tetraphenyl-2,3,7-triazaspiro[4.5]dec-7-ene-9-carboxylate derivatives were efficiently synthesized from readily available 1,2-diphenylpyrazolidine-3,5-dione, ethyl 2-fluoroacetoacetate, aromatic aldehydes, and ammonium acetate via one-pot four-component reactions in the absence of additional catalyst. In the protocols, ammonium acetate serves not only as the fourth component but also as the catalyst.
Key words
one-pot multicomponent reaction - ethyl 2-fluoroacetoacetate - 1,2-diphenylpyrazolidine-3,5-dione - fluorinated spiro-pyrazole-pyridine derivativesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1866-4653.
- Supporting Information (PDF)
Publication History
Received: 18 April 2022
Accepted after revision: 16 May 2022
Accepted Manuscript online:
01 June 2022
Article published online:
02 August 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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