Aktuelle Dermatologie 2022; 48(06): 271-274
DOI: 10.1055/a-1844-8977

Männer- und Frauenhaut – Genderaspekte[*]

Skin of Men and Women – Gender Aspects
Christiane Bayerl
1   Klinik für Dermatologie und Allergologie, Helios Dr. Horst Schmidt Kliniken, Hauttumorzentrum Wiesbaden
› Author Affiliations


Männer- und Frauenhaut sind unterschiedlich. Männerhaut ist dicker, hat mehr Talgdrüsen und Oberflächenlipide, eine höhere, nicht so divergente Keimzahl wie Frauen, niedrigere transepidermale Wasserverlust (TEWL)-Werte und einen niedrigeren pH-Wert. Die Wundheilung und das Niveau von Antioxidantien ist bei Frauenhaut besser. Männerhaut hat mehr Kollagen, altert an anderer Lokalisation, bei Männern finden sich mehr Falten an der Stirn, bei Frauen mehr Falten perioral. Studien sollten die Auswertung der Daten nach Geschlechtern mit beachten.


Skin of men and women is different in its structure. Skin of men is thicker, more sebaceous glands und surface lipids are found. The skin flora shows more bacteria, but less divergence compared to women, a lower level of transepidermal water loss (TEWL) und lower pH levels. Wound healing and the level of anti-oxidants is better in women. The skin of men shows more collagen, ages in different locations with more skin folds on the forehead whereas women show more skin folds in the perioral location. Studies should focus on evaluation of the data according to sex as well.

* Nach einem Referat gehalten bei der DermKompakt in Wiesbaden, Beautiful Sunday, 2/2022, Herrn Prof. Jung zum 90. Geburtstag zugedacht, Review Dr. Beate Schwarz, Langenau

Publication History

Article published online:
14 June 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

  • Literatur

  • 1 Manatis-Lornell AJ, Marks DH, Hagegeorges D. et al. Gender-related cost discrepancies in a cohort of 110 facial moisturizers. J Cosmet Dermatol 2019; 18: 1765-1766
  • 2 Riscia PM, Gans KM, Kumanyika S. et al. Sister Talk: final results of a culturally tailored cable television delivered weight control program for Black women. Int J Behav Nutr Phys Act 2013; 10: 141 DOI: 10.1186/1479-5868-10-141.
  • 3 Unnikrishnan A, Freeman WM, Jackson J. et al. The role for DNA methylation in epigenetics of aging. Pharmacol Ther 2019; 195: 172-185
  • 4 Gudjonsson JE, Kabashima K, Eyrich K. Mechanisms of skin autoimmunity: cellular and soluble immune components of the skin. J Allery Clin Immunol 2020; 146: 8-16
  • 5 Chen W, Mempel M, Traidl-Hofmann C. et al. Gender aspects in skin diseases. J Eur Acad Dermatol Venereol 2010; 24: 1378-1385
  • 6 Migeon BR. X-linked diseases: susceptible females. Genet Med 2020; 7: 1156-1174
  • 7 Kasperska-Zajac A, Brzoza Z, Rogala B. Sex hormones and urticaria. J Dermatol Sci 2008; 52: 79-86
  • 8 Colombo D, Banfi G, Cassano N. et al. The GENDER ATTENTION observational study: gender and hormonal status differences in the incidence of adverse events during cyclosporine treatment in psoriatic patients. Adv Ther 2017; 34: 1349-1363
  • 9 Fierer N, Hamady M, Lauber CL. et al. The influence of sex, handedness, and washing on the diversity of hand surface bacteria. Proc Natl Acad Sci U S A 2008; 105: 17994-17999
  • 10 Shi Ying, Zeng D-N, Chi L. et al. The influence of age and gender on skin-associated microbial communities in urban and rural human populations. PLoS One 2015; 10: c0141842 DOI: 10.1371/journal.pone.0141842.
  • 11 Leong PL. Aging changes in the male face. Facial Plast Surg Clin North Am 2008; 16: 277-279
  • 12 Firooz A, Rajabi-Estarabadi A, Zartab H. et al. The influence of gender and age on the thickness and echo-densitiy of skin. Skin Res Technol 2017; 23: 13-20
  • 13 Luebberding S, Krueger N, Kerscher M. Skin physiology in men and women: in vivo evaluation of 300 people including TEWL, SC hydration, sebum content and skin surface pH. Int J Cosmet Sci 2013; 35: 477-483
  • 14 Tsukahara K, Hotta M, Osanai O. et al. Gender-dependent differences in degree of facial wrinkles. Skin Res Technol 2013; 19: e65-e71
  • 15 Paes EC, Teepen HJKJM, Koop WA. et al. Perioral wrinkels: histologic differences between men and women. Aesthet Surg J 2009; 29: 467-472
  • 16 Hodges GJ, Sharp L, Clements RE. et al. Influence of age, sex and aerobic capacity on forerarm and skin blood flow and vascular conductance. Eur J Appl Physiol 2010; 109: 1009-1015
  • 17 Kenny JP, Jay O. Sex differences in postexercise esophageal and muscle tissue temperature response. Am J Physiol Regul Integr Comp Physiol 2007; 292: 1632-1640
  • 18 Jorgensen LN, Sorensen LT, Kallehave F. et al. Premenopausal women deposit more collagen than men during healing of an experimental wound. Surgery 2002; 131: 338-343
  • 19 Ye Y, Griffin MJ. Reductions in finger blood flow in men and women induced by 125-Hz vibration; association with vibration perception thresholds. J Appl Physiol 2011; 111: 1606-1613
  • 20 Cook IF. Sex differences in injection site reactions with human vaccines. Hum Vaccin 2009; 5: 441-449
  • 21 Henderson LA, Gandevia SC, Macefield VG. Gender differences in brain activity evoked by muscle and cutaneous pain: a retrospective study of single-trial fMRI data. Neuroimage 2008; 39: 1867-1876
  • 22 Witkos J, Hartman-Petrycka M. Gender differences in subjective pain perception during and after tattooing. Int J Environ Res Public Health 2020; 17: 9466 DOI: 10.3390/ijerph17249466.
  • 23 Fenske NA, Lober CW. Structural and functional changes of normal aging skin. J Am Acad Dermatol 1986; 15: 572-5385
  • 24 Russell R. A sex difference in facial contrast and its exaggeration by cosmetics. Reception 2009; 38: 1211-1219
  • 25 Nast A, Dréno B, Bettoli V. et al. European evidence-based (S3) guideline for the treatment of acne – update 2016 – short version. J Eur Acad Dermatol Venereol 2016; 30: 1261-1268
  • 26 Guinot C, Latreille J, Tenenhaus M. et al. Global classification of human facial healthy skin using PLS discriminant analysis and clustering analysis. Int J Cosmet Sci 2001; 23: 67-73
  • 27 Geier J, Schubert S, Schnuch A. et al. A negative breakdown test in a fragrance mix 1-positve patient does not rule out contact allergy to its fragrance constituents. Contact Dermatitis 2021; 84: 407-418
  • 28 OʼRioban DL, Steffen AD, Lunde KB. et al. A day at the beach while on tropical vacation: sun protections practices in a high-risk setting for UV radiation exposure. Arch Dermatol 2008; 144: 1449-1455
  • 29 Weinstock MA, Rossi JS, Redding CA. et al. Sun protection behaviors and stages of change for the primary prevention of skin cancers among beachgoers in southeastern New England. Ann Behav Med 2000; 22: 286-293
  • 30 Xu G, Snellman S, Bykov VJ. et al. Effect of age on the formation and repair of UV photoproducts in human skin in situ. Mutat Res 2000; 459: 195-202
  • 31 Damian DL, Patterson CR, Stapelberg M. et al. UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. J Invest Dermatol 2008; 128: 447-454
  • 32 Zhong Q-Y, Lin B, Chen Y-T. et al. Gender differences in UV-induced skin inflammation, skin carcinogenesis and systemic damage. Environ Toxicol Pharmacol 2021; 81: 103512 DOI: 10.1016/j.etap.2020.103512.
  • 33 Behbahani S, Maddukuri S, Cadwell JB. et al. Gender differences in cutaneous melanoma: demographics, prognostic factors, and survival outcomes. Dermatol Ther 2020; 33: e14131 DOI: 10.1111/dth.14131.
  • 34 Ross SS, Doxey AC, Neufeld JD. The skin microbiome of cohabiting couples. mSystems 2017; 2: e00043-17 DOI: 10.1128/mSystems.00043-17.